C. elegans
- Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis
Summary: When the C. elegans embryo experiences mechanical stress during its first cell division, the direction of cortical flow needs to change so cytokinesis can be completed.
- The RBG-1–RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans
Highlighted Article: Loss of function of the RBG-1-RBG-2 complex promotes lysosomal biogenesis and function, and also ameliorates the autophagy defect caused by mutations in the Vici syndrome gene EPG5.
- Anterior-enriched filopodia create the appearance of asymmetric membrane microdomains in polarizing C. elegans zygotes
Summary: Apparent accumulation of PIP2 and cortex/polarity-related proteins within plasma membrane microdomains in polarizing C. elegans zygotes reflects local membrane topology induced by filopodia, not selective enrichment within signaling domains.
- Structure and function analysis of the C. elegans aminophospholipid translocase TAT-1
Summary: The structure–function relationship of the C. elegans P4-ATPase TAT-1 and identification of two highly conserved motifs that are especially important for the TAT-1 phosphatidylserine flippase activity.
- The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis
Summary: The ATPase Afg1 has evolutionarily conserved roles in both oxidative stress tolerance and mitochondrial protein homeostasis, suggesting its importance in mitochondrial quality control.
- Local microtubule organization promotes cargo transport in C. elegans dendrites
Highlighted Article: Systematic analysis of microtubule organization in C. elegans neurons reveals distinct mechanisms that act in dendrites, where distal microtubule nucleation in ciliated neurons stimulates distal dendritic transport.
- CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/perlecan alternative splicing in the C. elegans epidermis
Summary: Loss of CCAR-1 function during C. elegans embryogenesis results in dysregulated alternative splicing of unc-52 (the homolog of mammalian perlecan) and hemidesmosome disruption.
- ImaEdge – a platform for quantitative analysis of the spatiotemporal dynamics of cortical proteins during cell polarization
Summary: An open-source software package, ImaEdge, automates the segmentation of the cell cortex from time-lapse movies, and enables quantitative extraction of cortical protein dynamics in cells undergoing polarization.
- Mind the (sr)GAP – roles of Slit–Robo GAPs in neurons, brains and beyond
Summary: A review of the functions of Slit–Robo GTPase-activating proteins (srGAPs), which are highly conserved proteins that interact with the plasma membrane, regulate Rho family GTPases, and function in a wide range of cell biological processes.
- Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells
Summary: Dynein and EFF-1 have a non-autonomous function in patterning PVD dendrites in C. elegans through epidermal SAX-7.