Ca2+ signalling
- Association of cardiac myosin-binding protein-C with the ryanodine receptor channel – putative retrograde regulation?
Highlighted Article: Myosin binding protein-C functionally interacts with the cardiac Ca2+ release channel (RyR2), suggesting a novel retrograde regulation mechanism for muscle excitation–contraction coupling.
- Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes
Highlighted Article: The availability of the membrane tether junctophilin-2 determines the nanostructure of the fast intracellular Ca2+ signalling junctions but, if present above a minimum required level, forms an auto-regulatory mechanism which maintains local Ca2+ signals broadly independent of the structural differences.
- Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM–Orai interactions in Drosophila neurons
Summary: In Drosophila neurons, mutant IP3 receptors disrupt store-operated Ca2+ entry by destabilizing interaction of STIM with the Ca2+ channel, Orai. The interactions could coordinate store emptying with Ca2+ entry.
- Ca2+ is a key factor in α-synuclein-induced neurotoxicity
Summary: Monomeric and oligomeric α-synuclein induce Ca2+ signal in neurons and astrocytes by incorporating into the membrane.