Caveolae
- Non-caveolar caveolins – duties outside the caves
Summary: In this Review, we revisit the non-canonical roles of caveolins in a variety of cellular contexts including liver, brain, lymphocytes, cilia and cancer cells, as well as consider insights from invertebrate systems.
- Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly
Highlighted Article: The assembly of respiratory syncytial virus occurs in caveolar membranes and caveolar coat components are incorporated into the viral envelope.
- Architecture of the caveolar coat complex
Highlighted Article: This paper reports the first structural analysis of the entire caveolar protein coat isolated intact from mammalian cells, and shows that the coat is composed of two morphologically distinct layers.
- Caveolae – mechanosensitive membrane invaginations linked to actin filaments
Summary: Caveolae and stress fibers are two essential players in the cell response to mechanical forces. The physical association of these two mechanosensors could ensure a coordinated response during mechanotransduction.
- Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane
Highlighted Article: Decreased membrane binding of PACSIN2 upon its PKC-mediated phosphorylation at serine 313 is shown to trigger the removal of caveolae from the plasma membrane.