Cdk5
- The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease
Highlighted Article: Cdk5-mediated degradation of Mcl-1 by direct phosphorylation promotes neurotoxicity. Mcl-1 upregulation, or Cdk5 inhibition, is potentially an attractive therapeutic strategy for preventing neurodegeneration in AD.
- Nestin contributes to skeletal muscle homeostasis and regeneration
Summary: Muscles from nestin-knockout mice have decreased mass, are prone to spontaneous degeneration/regeneration and have longer recovery time after injury. This phenotype is linked to disturbed proliferation of satellite cells.
- Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
Summary: The Cdk5–Foxo3 axis promotes neurotoxic β-amyloid processing and neuronal death in Alzheimer's disease models.