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Cdk5

  • RESEARCH ARTICLE
    The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy
    Shinya Matsuda, Ushio Kikkawa, Haruka Uda, Akio Nakashima
    Journal of Cell Science 2020 133: jcs247817 doi: 10.1242/jcs.247817 Published 9 September 2020

    Summary: In fission yeast, sexual differentiation is important for survival in environmental changes. We found that Pef1 regulates initiation of sexual differentiation through control of the TORC1 pathway and autophagy.

  • RESEARCH ARTICLE
    The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease
    Kumar Nikhil, Kavita Shah
    Journal of Cell Science 2017 130: 3023-3039; doi: 10.1242/jcs.205666

    Highlighted Article: Cdk5-mediated degradation of Mcl-1 by direct phosphorylation promotes neurotoxicity. Mcl-1 upregulation, or Cdk5 inhibition, is potentially an attractive therapeutic strategy for preventing neurodegeneration in AD.

  • RESEARCH ARTICLE
    Nestin contributes to skeletal muscle homeostasis and regeneration
    Julia Lindqvist, Elin Torvaldson, Josef Gullmets, Henok Karvonen, Andras Nagy, Pekka Taimen, John E. Eriksson
    Journal of Cell Science 2017 130: 2833-2842; doi: 10.1242/jcs.202226

    Summary: Muscles from nestin-knockout mice have decreased mass, are prone to spontaneous degeneration/regeneration and have longer recovery time after injury. This phenotype is linked to disturbed proliferation of satellite cells.

  • RESEARCH ARTICLE
    Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
    Chun Shi, Keith Viccaro, Hyoung-gon Lee, Kavita Shah
    Journal of Cell Science 2016 129: 1815-1830; doi: 10.1242/jcs.185009

    Summary: The Cdk5–Foxo3 axis promotes neurotoxic β-amyloid processing and neuronal death in Alzheimer's disease models.

  • COMMENTARY
    Cdk5 activity in the brain – multiple paths of regulation
    Kavita Shah, Debomoy K. Lahiri
    Journal of Cell Science 2014 127: 2391-2400; doi: 10.1242/jcs.147553
  • RESEARCH ARTICLE
    Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death
    Kuei-Hua Chang, Fabien Vincent, Kavita Shah
    Journal of Cell Science 2012 125: 5124-5137; doi: 10.1242/jcs.108183

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