Cell growth
- Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses
Summary: Endosomal sorting complex required for transport (ESCRT)-I destabilization upon concurrent depletion of Vps37 proteins is linked to the activation of a sterile inflammatory response and cell growth inhibition.
- An image analysis method to survey the dynamics of polar protein abundance in the regulation of tip growth
Summary: Large-scale time-lapse analysis of individual tip growth and polar factor abundance in yeast and filamentous fungi reveals limits to tip surface expansion rates that are independent of local remodeling activity.
- Nutrient regulation of mTORC1 at a glance
Summary: A summary of how extracellular and intracellular signals feed into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis.
- Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription
Summary: In nitrogen-poor medium, inhibition of Cdk1 becomes essential for generating a proper wave of MBF-dependent transcription at G1/S, which prevents DNA replication stress.
- Genome-wide screen for cell growth regulators in fission yeast
Summary: Using a novel system to identify cell growth regulators, we have discovered a number of factors that activate growth in cells in which growth is developmentally switched off.