Chondrogenesis
- BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation
Summary: GDF5 mutants were used to investigate the role of BMPR1A and BMPR1B in chondrogenesis and osteogenesis. We found that BMPR1A is necessary for chondrogenesis and osteogenesis, and BMPR1B prevents hypertrophy.
- HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development
Highlighted Article: HES1 and HES5 are new regulators of chondrogenesis and chondrocyte hypertrophy during cartilage development, with HES5 playing a previously unidentified role in modulating Sox9 transcription.
- Control of Wnt5b secretion by Wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression
Summary: Wntless-mediated Wnt5b secretion modulates the proliferation of chondrogenic cells through fine-tuning regional Fgf3 expression during the development of craniofacial cartilages.