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Connexin

  • RESEARCH ARTICLE
    The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss
    John J. Kelly, Julia M. Abitbol, Stephanie Hulme, Eric R. Press, Dale W. Laird, Brian L. Allman
    Journal of Cell Science 2019 132: jcs224097 doi: 10.1242/jcs.224097 Published 16 January 2019

    Summary: The Clouston syndrome-causing connexin 30 mutant (Cx30-A88V) provides long-term protection against age-related hair cell death and hearing loss in mice.

  • RESEARCH ARTICLE
    Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss
    Julia M. Abitbol, John J. Kelly, Kevin J. Barr, Brian L. Allman, Dale W. Laird
    Journal of Cell Science 2018 131: jcs214635 doi: 10.1242/jcs.214635 Published 4 May 2018

    Summary: Mutant mice harbouring a severe loss-of-function mutation in Gja1, encoding Cx43, that is associated with the human-linked disease oculodentodigital dysplasia, leads to severe hearing loss and central auditory defects.

  • RESEARCH ARTICLE
    Connexin hemichannels mediate glutathione transport and protect lens fiber cells from oxidative stress
    Wen Shi, Manuel A. Riquelme, Sumin Gu, Jean X. Jiang
    Journal of Cell Science 2018 131: jcs212506 doi: 10.1242/jcs.212506 Published 21 March 2018

    Summary: Connexin hemichannels activated by oxidative stress in lens fiber cells mediate a cell protective mechanism through the uptake of reductants, maintaining lens transparency and homeostasis.

  • RESEARCH ARTICLE
    Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions
    Anuttoma Ray, Parul Katoch, Nimansha Jain, Parmender P. Mehta
    Journal of Cell Science 2018 131: jcs207340 doi: 10.1242/jcs.207340 Published 2 March 2018

    Highlighted Article: The C-terminal tail of connexin32 harbors two dileucine-based sorting motifs and an uncanonical motif. These motifs govern the endocytosis of connexin32 and affect its ability to form gap junctions differently.

  • RESEARCH ARTICLE
    Regulation of Cx37 channel and growth-suppressive properties by phosphorylation
    Nicole L. Jacobsen, Tasha K. Pontifex, Hanjun Li, Joell L. Solan, Paul D. Lampe, Paul L. Sorgen, Janis M. Burt
    Journal of Cell Science 2017 130: 3308-3321; doi: 10.1242/jcs.202572

    Summary: Connexin 37 may serve as a molecular switch that contributes to cell fate decisions, between cell cycle arrest, cell cycle progression and cell death, in a phosphorylation- and channel-dependent manner.

  • RESEARCH ARTICLE
    The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
    Max Z. Totland, Christian H. Bergsland, Tone A. Fykerud, Lars M. Knudsen, Nikoline L. Rasmussen, Peter W. Eide, Zeremariam Yohannes, Vigdis Sørensen, Andreas Brech, Ragnhild A. Lothe, Edward Leithe
    Journal of Cell Science 2017 130: 2867-2882; doi: 10.1242/jcs.202408

    Highlighted Article: The proto-oncogenic E3 ubiquitin ligase NEDD4 induces ubiquitylation and lysosomal degradation of connexin 43, a protein that is often dysregulated during cancer development, resulting in loss of gap junctions in human carcinoma cells.

  • TOOLS AND TECHNIQUES
    Localization of phosphorylated connexin 43 using serial section immunogold electron microscopy
    Rachael P. Norris, Valentina Baena, Mark Terasaki
    Journal of Cell Science 2017 130: 1333-1340; doi: 10.1242/jcs.198408

    Highlighted Article: Here, we show how new 3D electron microscopy techniques can be extended to investigate ultrastructural protein localization in order to advance insight into mechanisms of gap junction internalization.

  • RESEARCH ARTICLE
    Myosin VI facilitates connexin 43 gap junction accretion
    Bennett J. Waxse, Prabuddha Sengupta, Geoffrey G. Hesketh, Jennifer Lippincott-Schwartz, Folma Buss
    Journal of Cell Science 2017 130: 827-840; doi: 10.1242/jcs.199083

    Highlighted Article: Myosin VI localizes to gap junctions in a variety of cell types and tissues, where this motor regulates gap junction plaque size through interaction with cortical actin.

  • RESEARCH ARTICLE
    Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration
    Srikanth R. Polusani, Edward A. Kalmykov, Anjana Chandrasekhar, Shoshanna N. Zucker, Bruce J. Nicholson
    Journal of Cell Science 2016 129: 4399-4410; doi: 10.1242/jcs.185017

    Summary: Gap junction expression has been linked to enhanced metastasis and cell migration. We show here that Cx26 gap junctions selectively enhance cell migration by disrupting N-cadherin-based cell adhesion in HeLa cells.

  • RESEARCH ARTICLE
    Two-color fluorescent analysis of connexin 36 turnover: relationship to functional plasticity
    Helen Yanran Wang, Ya-Ping Lin, Cheryl K. Mitchell, Sripad Ram, John O'Brien
    Journal of Cell Science 2015 128: 3888-3897; doi: 10.1242/jcs.162586

    Summary: Fluorescent labeling of Cx36-HaloTag revealed that turnover occurs on a different time scale than phosphorylation-driven plasticity. Cx36-HaloTag is also partially mobile within gap junctions.

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