Cx30
- The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss
Summary: The Clouston syndrome-causing connexin 30 mutant (Cx30-A88V) provides long-term protection against age-related hair cell death and hearing loss in mice.
- Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctions
Highlighted Article: The gap junction protein Cx30 was found to be an unusually stable, long-lived connexin, which might underlie its specific role in the epidermis and cochlea.