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Degradation

  • REVIEW
    p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy
    Alberto Danieli, Sascha Martens
    Journal of Cell Science 2018 131: jcs214304 doi: 10.1242/jcs.214304 Published 4 October 2018

    Summary: This review highlights the recent advances of how the ubiquitin-proteasome system and autophagy can be coordinated by p62-dependent phase separation reactions.

  • RESEARCH ARTICLE
    The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation
    Daniela Gödderz, Tatiana A. Giovannucci, Jana Laláková, Victoria Menéndez-Benito, Nico P. Dantuma
    Journal of Cell Science 2017 130: 3336-3346; doi: 10.1242/jcs.202622

    Summary: The deubiquitylating enzyme Ubp12 targets the ubiquitin shuttle factor Rad23 and stabilizes proteasome substrates that are delivered by Rad23, uncovering a novel link between ubiquitin and proteasomal degradation.

  • RESEARCH ARTICLE
    The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
    Max Z. Totland, Christian H. Bergsland, Tone A. Fykerud, Lars M. Knudsen, Nikoline L. Rasmussen, Peter W. Eide, Zeremariam Yohannes, Vigdis Sørensen, Andreas Brech, Ragnhild A. Lothe, Edward Leithe
    Journal of Cell Science 2017 130: 2867-2882; doi: 10.1242/jcs.202408

    Highlighted Article: The proto-oncogenic E3 ubiquitin ligase NEDD4 induces ubiquitylation and lysosomal degradation of connexin 43, a protein that is often dysregulated during cancer development, resulting in loss of gap junctions in human carcinoma cells.

  • RESEARCH ARTICLE
    LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1
    Chunbin Zou, Matthew J. Synan, Jin Li, Sheng Xiong, Michelle L. Manni, Yuan Liu, Bill B. Chen, Yutong Zhao, Sruti Shiva, Yulia Y. Tyurina, Jianfei Jiang, Janet S. Lee, Sudipta Das, Anuradha Ray, Prabir Ray, Valerian E. Kagan, Rama K. Mallampalli
    Journal of Cell Science 2016 129: 51-64; doi: 10.1242/jcs.176701

    Highlighted Article: This study provides new insight into how endotoxin triggers depletion of a key mitochondrial enzyme, Alcat1, by activating an SCF ubiquitin E3 ligase complex that contains Fbxo28.

  • RESEARCH ARTICLE
    Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability
    Olga Vagin, Elmira Tokhtaeva, Patton E. Garay, Puneet Souda, Sara Bassilian, Julian P. Whitelegge, Ramilla Lewis, George Sachs, Larry Wheeler, Roger Aoki, Ester Fernandez-Salas
    Journal of Cell Science 2014 127: 3294-3308; doi: 10.1242/jcs.146324
  • RESEARCH ARTICLE
    Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe
    Andrea Krapp, Viesturs Simanis
    Journal of Cell Science 2014 127: 3149-3161; doi: 10.1242/jcs.148585
  • RESEARCH ARTICLE
    BAG6 regulates the quality control of a polytopic ERAD substrate
    Aishwarya Payapilly, Stephen High
    Journal of Cell Science 2014 127: 2898-2909; doi: 10.1242/jcs.145565
  • RESEARCH ARTICLE
    Isoform 5 of PIPKIγ regulates the endosomal trafficking and degradation of E-cadherin
    Nicholas J. Schill, Andrew C. Hedman, Suyong Choi, Richard A. Anderson
    Journal of Cell Science 2014 127: 2189-2203; doi: 10.1242/jcs.132423

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