Degradation
- An evolutionarily distinct chaperone promotes 20S proteasome α-ring assembly in plants
Highlighted Article: PBAC5 is an evolutionarily distinct chaperone that forms a tripartite complex with PBAC1 and PBAC2 to promote assembly of the 20S proteasome α-ring in Arabidopsis.
- p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy
Summary: This review highlights the recent advances of how the ubiquitin-proteasome system and autophagy can be coordinated by p62-dependent phase separation reactions.
- The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation
Summary: The deubiquitylating enzyme Ubp12 targets the ubiquitin shuttle factor Rad23 and stabilizes proteasome substrates that are delivered by Rad23, uncovering a novel link between ubiquitin and proteasomal degradation.
- The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
Highlighted Article: The proto-oncogenic E3 ubiquitin ligase NEDD4 induces ubiquitylation and lysosomal degradation of connexin 43, a protein that is often dysregulated during cancer development, resulting in loss of gap junctions in human carcinoma cells.
- LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1
Highlighted Article: This study provides new insight into how endotoxin triggers depletion of a key mitochondrial enzyme, Alcat1, by activating an SCF ubiquitin E3 ligase complex that contains Fbxo28.