DNA repair
- Overexpression of PP1–NIPP1 limits the capacity of cells to repair DNA double-strand breaks
Highlighted Article: By expressing fusions between PP1 and NIPP1, we selectively study the function of the PP1:NIPP1 holoenzyme and find that this phosphatase limits the capacity to repair DNA double-strand breaks.
- Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe
Summary: Cohesin methylation is a novel post-translational modification implicated in DNA repair in the fission yeast S. pombe.
- Mitochondrial maintenance under oxidative stress depends on mitochondrially localised α-OGG1
Summary: The α-isoform of OGG1 is imported into mitochondria, where its glycosylase activity is essential for mitochondrial maintenance in human cells exposed to oxidative stress.
- Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium
Highlighted Article: The DNA repair nuclease Xpf helps to maintain the integrity of the genome during bacterial phagocytosis in the amoeba Dictyostelium.
- CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity
Summary: Knockout of the CEP164 ciliopathy gene ablates ciliogenesis but causes no increase in sensitivity to DNA damage induced by ionising or ultraviolet irradiation.