E-cadherin
- SHP-2 is activated in response to force on E-cadherin and dephosphorylates vinculin Y822
Summary: Here, we employ a novel technique to manipulate phosphatases, revealing a mechanism for how force transmission is switched off or reset.
- Novel role for Grainy head in the regulation of cytoskeletal and junctional dynamics during epithelial repair
Highlighted Article: The transcription factor Grainy head is involved in tissue repair, through ensuring the formation of a proper contractile actomyosin cable and the regulation of adherens junction dynamics.
- E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine
Summary: Epithelial tissues should permit cell proliferation without losing their integrity for homeostasis. MT2-MMP protease cleaves E-cadherin at apical junctions, promoting regulated exit from quiescence in epithelial cells in the intestine.
- Attenuation of N-glycosylation causes polarity and adhesion defects in the C. elegans embryo
Summary: Upon reduction of N-glycosylation, E-cadherin is not efficiently localized in the cell–cell contact site contributing to adhesion defects in the two-cell C. elegans embryo. This phenotype is rescued by concomitant loss of cell polarity.
- Cortactin is a scaffolding platform for the E-cadherin adhesion complex and is regulated by protein kinase D1 phosphorylation
Summary: Cortactin and its phosphorylation by protein kinase D1 at S298 modulate E-cadherin adhesion complex composition and F-actin linkage during ligation and dissolution of adherence junctions.
- E-cadherin-mediated force transduction signals regulate global cell mechanics
Summary: Force transduction at E-cadherin junctions operates in addition to unfurling of cadherin-associated α-catenin. This pathway requires EGFR and triggers the downstream activation of integrin-dependent cell contractility.
- FGF control of E-cadherin targeting in the Drosophila midgut impacts on primordial germ cell motility
Summary: FGF signaling modulates zygotic E-cadherin distribution to maintain posterior midgut epithelial 3D architecture, impacting on primordial germ cell motility during Drosophila early embryonic development.
- EGF augments TGFβ-induced epithelial–mesenchymal transition by promoting SHP2 binding to GAB1
Highlighted Article: By activating ERK1/2, the protein tyrosine phosphatase SHP2 tunes the extent of the epithelial–mesenchymal transition observed in carcinoma cells in response to different growth factors.