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E-cadherin

  • RESEARCH ARTICLE
    SHP-2 is activated in response to force on E-cadherin and dephosphorylates vinculin Y822
    Hannah Campbell, Christy Heidema, Daisy G. Pilarczyk, Kris A. DeMali
    Journal of Cell Science 2018 131: jcs216648 doi: 10.1242/jcs.216648 Published 14 December 2018

    Summary: Here, we employ a novel technique to manipulate phosphatases, revealing a mechanism for how force transmission is switched off or reset.

  • RESEARCH ARTICLE
    Novel role for Grainy head in the regulation of cytoskeletal and junctional dynamics during epithelial repair
    Inês Cristo, Lara Carvalho, Susana Ponte, António Jacinto
    Journal of Cell Science 2018 131: jcs213595 doi: 10.1242/jcs.213595 Published 3 September 2018

    Highlighted Article: The transcription factor Grainy head is involved in tissue repair, through ensuring the formation of a proper contractile actomyosin cable and the regulation of adherens junction dynamics.

  • RESEARCH ARTICLE
    E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine
    Jesús Gómez-Escudero, Vanessa Moreno, Mara Martín-Alonso, M. Victoria Hernández-Riquer, Tamar Feinberg, Ángel Colmenar, Enrique Calvo, Emilio Camafeita, Fernando Martínez, Menno J. Oudhoff, Stephen J. Weiss, Alicia G. Arroyo
    Journal of Cell Science 2017 130: 4013-4027; doi: 10.1242/jcs.203687

    Summary: Epithelial tissues should permit cell proliferation without losing their integrity for homeostasis. MT2-MMP protease cleaves E-cadherin at apical junctions, promoting regulated exit from quiescence in epithelial cells in the intestine.

  • SHORT REPORT
    Attenuation of N-glycosylation causes polarity and adhesion defects in the C. elegans embryo
    Julia Stevens, Anne Spang
    Journal of Cell Science 2017 130: 1224-1231; doi: 10.1242/jcs.189316

    Summary: Upon reduction of N-glycosylation, E-cadherin is not efficiently localized in the cell–cell contact site contributing to adhesion defects in the two-cell C. elegans embryo. This phenotype is rescued by concomitant loss of cell polarity.

  • RESEARCH ARTICLE
    Cortactin is a scaffolding platform for the E-cadherin adhesion complex and is regulated by protein kinase D1 phosphorylation
    Robert Sroka, Johan Van Lint, Sarah-Fee Katz, Marlon R. Schneider, Alexander Kleger, Stephan Paschke, Thomas Seufferlein, Tim Eiseler
    Journal of Cell Science 2016 129: 2416-2429; doi: 10.1242/jcs.184721

    Summary: Cortactin and its phosphorylation by protein kinase D1 at S298 modulate E-cadherin adhesion complex composition and F-actin linkage during ligation and dissolution of adherence junctions.

  • RESEARCH ARTICLE
    E-cadherin-mediated force transduction signals regulate global cell mechanics
    Ismaeel Muhamed, Jun Wu, Poonam Sehgal, Xinyu Kong, Arash Tajik, Ning Wang, Deborah E. Leckband
    Journal of Cell Science 2016 129: 1843-1854; doi: 10.1242/jcs.185447

    Summary: Force transduction at E-cadherin junctions operates in addition to unfurling of cadherin-associated α-catenin. This pathway requires EGFR and triggers the downstream activation of integrin-dependent cell contractility.

  • RESEARCH ARTICLE
    FGF control of E-cadherin targeting in the Drosophila midgut impacts on primordial germ cell motility
    Guillem Parés, Sara Ricardo
    Journal of Cell Science 2016 129: 354-366; doi: 10.1242/jcs.174284

    Summary: FGF signaling modulates zygotic E-cadherin distribution to maintain posterior midgut epithelial 3D architecture, impacting on primordial germ cell motility during Drosophila early embryonic development.

  • RESEARCH ARTICLE
    EGF augments TGFβ-induced epithelial–mesenchymal transition by promoting SHP2 binding to GAB1
    Janine M. Buonato, Ingrid S. Lan, Matthew J. Lazzara
    Journal of Cell Science 2015 128: 3898-3909; doi: 10.1242/jcs.169599

    Highlighted Article: By activating ERK1/2, the protein tyrosine phosphatase SHP2 tunes the extent of the epithelial–mesenchymal transition observed in carcinoma cells in response to different growth factors.

  • RESEARCH ARTICLE
    FilGAP, a Rho–ROCK-regulated GAP for Rac, controls adherens junctions in MDCK cells
    Shinichiro Nakahara, Koji Tsutsumi, Takuya Zuinen, Yasutaka Ohta
    Journal of Cell Science 2015 128: 2047-2056; doi: 10.1242/jcs.160192
  • RESEARCH ARTICLE
    Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo
    Dayana Krawchuk, Shihadeh Anani, Nobuko Honma-Yamanaka, Samantha Polito, Marian Shafik, Yojiro Yamanaka
    Journal of Cell Science 2015 128: 1011-1022; doi: 10.1242/jcs.162156

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