Elasticity
- Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization
Highlighted Article: Selection for tumour cells that efficiently pass through narrow diameter microporous membranes reveals a prominent role for MAPK signalling in regulating cell elasticity.
- Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma
Highlighted Article: Matrix stiffness modulates OSCC cell migration similarly to that of other epithelial carcinomas but by using a different focal-adhesion-mediated mechanism.
- Membrane fluctuations and acidosis regulate cooperative binding of ‘marker of self’ protein CD47 with the macrophage checkpoint receptor SIRPα
Summary: Binding of membrane proteins smooths the fluctuating membrane and facilitates more binding, which can be very important for weak immunological interactions such as the interaction of macrophage SIRPα with CD47 on cancer cells.