EMT
- Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1
Summary: Clusterin is identified to interact with extracellular Hsp90α and modulate its pro-metastatic function through increasing the binding affinity of eHsp90α and LRP1.
- Loss of CAMSAP3 promotes EMT via the modification of microtubule–Akt machinery
Summary: Removal of CAMSAP3, a protein that binds the microtubule minus-ends, promotes epithelial-to-mesenchymal transition in lung cancer-derived cells via enhancement of tubulin acetylation and Akt activation.
- AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation
Highlighted Article: Pharmacological and physiological activation of AMPK promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation and its increased nuclear localization.
- DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage
Summary: Alkylation damage induced cellular transformation in breast acinar cultures, which was partially rescued by DNA-PK inhibition.
- The Aurora-A–Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma
Summary: We show that the AURKA–Twist1 axis regulates EMT, xenograft growth and drug resistance in pancreatic cancer. This is the first mechanism linking AURKA activity with tumor metastasis through Twist1.
- Localized translation regulates cell adhesion and transendothelial migration
Summary: Translation affects adhesion and invasion potential of spreading initiation centers (SICs) producing mesenchymal cells, but not epithelial cells, which are deprived of SICs