Endoplasmic reticulum stress
- From the unfolded protein response to metabolic diseases – lipids under the spotlight
Summary: This Review focuses on the role of lipid bilayer stress-induced UPR in ER homeostasis and discusses the sensing mechanism and its contribution to metabolic diseases.
- TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus
Highlighted Article: Deficiency of the protein kinase Tak1 protects cells against endoplasmic reticulum stress through activation of de novo lipogenesis, which prevents leptin resistance in the hypothalamus and hyperphagic obesity.