Epithelial–mesenchymal transition
- BMP4 promotes the metastasis of gastric cancer by inducing epithelial–mesenchymal transition via ID1
Summary: BMP4 is a novel prognostic factor for gastric cancer that modulates epithelial–mesenchymal transition to promote invasion and metastasis by increasing ID1 expression.
- 5-Aza-2′-deoxycytidine advances the epithelial–mesenchymal transition of breast cancer cells by demethylating Sipa1 promoter-proximal elements
Summary: Hypomethylation by 5-Aza-CdR upregulates the SIPA1 expression and promotes epithelial–mesenchymal transition in breast cancer cells, possibly increasing the risk of cancer cell metastasis.
- Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement
Summary: Epitheliocytes cannot develop the F-actin patterns typically observed in fibroblasts, but can do so after treatments affecting actin polymerization. Regulators of actin polymerization, DIAPH1 and VASP, control this process.
- The filamin-B–refilin axis – spatiotemporal regulators of the actin-cytoskeleton in development and disease
Summary: Refilins behave as spatiotemporal regulators of the actin-bundling function of filamin and contribute to mechanosensory functions of filamin-B during vertebrate skeletal development.