ERK1/2
- CXCL2 attenuates osteoblast differentiation by inhibiting the ERK1/2 signaling pathway
Highlighted Article: The inflammatory chemokine CXCL2 has an important role in the pathogenesis of osteoporosis and attenuates osteogenesis by inhibiting differentiation of osteoblasts through ERK1/2 signaling.
- ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling
Summary: Phosphorylation by ERK1/2 stimulates transcriptional activity of hypoxia-inducible factor-2α by inhibiting its CRM1- and NES-dependent nuclear export.
- Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5
Summary: Our studies describe a new, multi-level paradigm in which allosteric modifications alter the ability of the scaffold protein Shoc2 to actively accelerate transmission of ERK1/2 signals.