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ESCRT

  • RESEARCH ARTICLE
    Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses
    Krzysztof Kolmus, Purevsuren Erdenebat, Ewelina Szymańska, Blair Stewig, Krzysztof Goryca, Edyta Derezińska-Wołek, Anna Szumera-Ciećkiewicz, Marta Brewińska-Olchowik, Katarzyna Piwocka, Monika Prochorec-Sobieszek, Michał Mikula, Marta Miączyńska
    Journal of Cell Science 2021 134: jcs250951 doi: 10.1242/jcs.250951 Published 8 January 2021

    Summary: Endosomal sorting complex required for transport (ESCRT)-I destabilization upon concurrent depletion of Vps37 proteins is linked to the activation of a sterile inflammatory response and cell growth inhibition.

  • RESEARCH ARTICLE
    ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing
    Matías Capella, Lucía Martín Caballero, Boris Pfander, Sigurd Braun, Stefan Jentsch
    Journal of Cell Science 2020 133: jcs250688 doi: 10.1242/jcs.250688 Published 21 December 2020

    Highlighted Article: Heh1-S, the inner nuclear membrane protein resulting from Hub1-mediated splicing of HEH1 pre-mRNA, contributes to nuclear envelope maintenance by preventing excessive recruitment of the ESCRT adaptor Chm7.

  • REVIEW
    The ESCRTs – converging on mechanism
    Mark Remec Pavlin, James H. Hurley
    Journal of Cell Science 2020 133: jcs240333 doi: 10.1242/jcs.240333 Published 16 September 2020

    Summary: New structural and biophysical studies have shed much light on the physical mechanism of ESCRT-mediated membrane remodeling and scission.

  • RESEARCH ARTICLE
    SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor
    Junya Hasegawa, Imen Jebri, Hikaru Yamamoto, Kazuya Tsujita, Emi Tokuda, Hideki Shibata, Masatoshi Maki, Toshiki Itoh
    Journal of Cell Science 2019 132: jcs229179 doi: 10.1242/jcs.229179 Published 3 October 2019

    Summary: A phosphoinositide-binding protein SH3YL1 binds to an ESCRT-I component Vps37B and plays an indispensable role in the degradative endosomal sorting of EGFR.

  • REVIEW
    Ubiquitin recognition in endocytic trafficking – with or without ESCRT-0
    Niccolò Mosesso, Marie-Kristin Nagel, Erika Isono
    Journal of Cell Science 2019 132: jcs232868 doi: 10.1242/jcs.232868 Published 15 August 2019

    Summary: ESCRT-0 is a heterodimeric ubiquitin receptor involved in endosomal trafficking, that has been acquired in opisthokonts and missing in other organisms. We discuss how other multicellular organisms, such as plants, recognise ubiquitylated cargoes.

  • RESEARCH ARTICLE
    The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks
    Nicola De Franceschi, Maryam Alqabandi, Nolwenn Miguet, Christophe Caillat, Stephanie Mangenot, Winfried Weissenhorn, Patricia Bassereau
    Journal of Cell Science 2019 132: jcs217968 doi: 10.1242/jcs.217968 Published 3 August 2018

    Summary: We present a new methodology to reconstitute proteins on membranes with complex geometry by means of vesicle fusion, unveiling a putative novel function of CHMP2B as a diffusion barrier in dendritic spines.

  • RESEARCH ARTICLE
    Lipid droplet consumption is functionally coupled to vacuole homeostasis independent of lipophagy
    Sarah Ouahoud, Mitchell D. Fiet, Fernando Martínez-Montañés, Christer S. Ejsing, Oliver Kuss, Michael Roden, Daniel F. Markgraf
    Journal of Cell Science 2018 131: jcs213876 doi: 10.1242/jcs.213876 Published 11 June 2018

    Highlighted Article: A genome-wide screen in budding yeast reveals that the functional status of vacuoles is relayed to lipid droplets to regulate their efficient utilization, independently of lipophagy.

  • RESEARCH ARTICLE
    An intracellular activation of Smoothened that is independent of Hedgehog stimulation in Drosophila
    Kai Jiang, Yajuan Liu, Jie Zhang, Jianhang Jia
    Journal of Cell Science 2018 131: jcs211367 doi: 10.1242/jcs.211367 Published 4 January 2018

    Highlighted Article: The interruption of the intracellular trafficking of Smo before it undergoes lysosome-mediated degradation leads to a high level of Smo accumulation, which is activated independently of ligand stimulation.

  • RESEARCH ARTICLE
    ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation
    James R. Edgar, Katarina Willén, Gunnar K. Gouras, Clare E. Futter
    Journal of Cell Science 2015 128: 2520-2528; doi: 10.1242/jcs.170233

    Highlighted Article: The early ESCRT machinery has a dual role in limiting intracellular Aβ accumulation through targeting of APP and its processing products to lysosomes for degradation, and promoting Aβ secretion.

  • RESEARCH ARTICLE
    Btn3 regulates the endosomal sorting function of the yeast Ent3 epsin, an adaptor for SNARE proteins
    Joëlle Morvan, Johan-Owen de Craene, Bruno Rinaldi, Vanessa Addis, Cédric Misslin, Sylvie Friant
    Journal of Cell Science 2015 128: 706-716; doi: 10.1242/jcs.159699

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