ESCRT
- The ESCRTs – converging on mechanism
Summary: New structural and biophysical studies have shed much light on the physical mechanism of ESCRT-mediated membrane remodeling and scission.
- SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor
Summary: A phosphoinositide-binding protein SH3YL1 binds to an ESCRT-I component Vps37B and plays an indispensable role in the degradative endosomal sorting of EGFR.
- Ubiquitin recognition in endocytic trafficking – with or without ESCRT-0
Summary: ESCRT-0 is a heterodimeric ubiquitin receptor involved in endosomal trafficking, that has been acquired in opisthokonts and missing in other organisms. We discuss how other multicellular organisms, such as plants, recognise ubiquitylated cargoes.
- The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks
Summary: We present a new methodology to reconstitute proteins on membranes with complex geometry by means of vesicle fusion, unveiling a putative novel function of CHMP2B as a diffusion barrier in dendritic spines.
- Lipid droplet consumption is functionally coupled to vacuole homeostasis independent of lipophagy
Highlighted Article: A genome-wide screen in budding yeast reveals that the functional status of vacuoles is relayed to lipid droplets to regulate their efficient utilization, independently of lipophagy.
- An intracellular activation of Smoothened that is independent of Hedgehog stimulation in Drosophila
Highlighted Article: The interruption of the intracellular trafficking of Smo before it undergoes lysosome-mediated degradation leads to a high level of Smo accumulation, which is activated independently of ligand stimulation.
- ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation
Highlighted Article: The early ESCRT machinery has a dual role in limiting intracellular Aβ accumulation through targeting of APP and its processing products to lysosomes for degradation, and promoting Aβ secretion.