Golgi complex
- The role of microtubules in secretory protein transport
Summary: Microtubules are important regarding various steps of protein transport. Regulation of their functions is achieved by protein interactions but also by post-translational modifications of tubulin.
- Glycosphingolipid metabolism in cell fate specification
Summary: Glycosphingolipids are emerging as powerful determinants in differentiation events. Here, we review the existing literature on the role of glycosphingolipids in cell fate determination.
- Golgi localization of oxysterol binding protein-related protein 4L (ORP4L) is regulated by ligand binding
Summary: ORP4L localization to contact sites between the Golgi and endoplasmic reticulum involves interaction with OSBP and PI(4)P, and is required for organelle structure and PI(4)P content.
- Multiple activities of Arl1 GTPase in the trans-Golgi network
Summary: Overview of the multiple cellular and physiological functions of Arl1 at the TGN, focusing on the associated regulators and effectors, and the pathways they control.
- 3D electron tomography of brain tissue unveils distinct Golgi structures that sequester cytoplasmic contents in neurons
Summary: The power of new 3D imaging technologies, and optimal preservation of tissue samples, has helped to identify previously uncharacterized Golgi structures that sequester cytoplasmic material in neurons.
- COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions
Summary: Under basal and sterol-deficient conditions, SCAP in complex with SREBP is retrieved from the Golgi complex in a COPI-dependent manner after it has been transported from the ER.
- A role for F-BAR protein Rga7p during cytokinesis in S. pombe
Summary: F-BAR protein Rga7p is required for the timely delivery of a β-glucan synthetase (Bgs4p) to the cleavage furrow during cytokinesis of fission yeast.
- The myelin proteolipid plasmolipin forms oligomers and induces liquid-ordered membranes in the Golgi complex
Summary: Investigation of the intracellular dynamics of plasmolipin reveals that it assembles potential myelin membrane precursor domains at the Golgi complex by oligomerizing and attracting liquid-ordered lipids.
- JNK2 controls fragmentation of the Golgi complex and the G2/M transition through phosphorylation of GRASP65
Summary: JNK2-mediated phosphorylation of GRASP65 at Ser277 has a crucial role in the G2-specific separation of the Golgi stacks that is required for the G2/M transition.