Heat stress
- Sequestration of the PKC ortholog Pck2 in stress granules as a feedback mechanism of MAPK signaling in fission yeast
Summary: Pmk1 regulates Pck2 recruitment into stress granules (SGs) upon heat stress, which intercepts MAPK signaling activation, indicating that SGs sequester active Pck2 in a feedback mechanism.
- TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules
Highlighted Article: The Drosophila TOR complex 2 is necessary for the formation of heat-induced cytoprotective stress granules, which can explain the heat sensitivity of TORC2 mutant flies.