Her2
- The MEF2–HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro
Summary: The HER2 oncogene alters the epithelial morphogenetic program and inhibits MEF2 transcriptional programs. Reactivation of MEF2s re-established normal acini morphogenesis.
- Mecp2 regulates neural cell differentiation by suppressing the Id1 to Her2 axis in zebrafish
Summary: Mecp2 suppresses neural cell development by suppressing the Id1–Her2 (Hes5 in mammals) axis, which is a mechanism that might contribute to the later motor and cognitive dysfunctions in Rett syndrome.