Hippocampus
- Signaling pathways controlling activity-dependent local translation of BDNF and their localization in dendritic arbors
Summary: BDNF mRNA is targeted to dendrites and translated locally. We describe the compartments and the signaling cascades required for local BDNF translation in dendrites in response to excitatory inputs.
- TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching
Highlighted Article: By interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning.
- CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons
Summary: Our results reveal new functions of endogenous CAPS1 in the BDNF secretory granule life cycle thereby representing a new mechanism of neuronal plasticity.