Hippocampus
- AstroDot – a new method for studying the spatial distribution of mRNA in astrocytes
Summary: AstroDot is a new method for studying the spatial distribution of mRNA ex vivo in complex brain cells, such as astrocytes and microglia, in physiological and pathological conditions.
- A retention–release mechanism based on RAB11FIP2 for AMPA receptor synaptic delivery during long-term potentiation
Summary: RAB11FIP2 associates with AMPA receptors on immobile endosomal compartments, separate from Rab11. After LTP induction, FIP2 disengages from the receptor, allowing synaptic delivery and potentiation.
- Signaling pathways controlling activity-dependent local translation of BDNF and their localization in dendritic arbors
Summary: BDNF mRNA is targeted to dendrites and translated locally. We describe the compartments and the signaling cascades required for local BDNF translation in dendrites in response to excitatory inputs.
- TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching
Highlighted Article: By interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning.
- CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons
Summary: Our results reveal new functions of endogenous CAPS1 in the BDNF secretory granule life cycle thereby representing a new mechanism of neuronal plasticity.