HMGB1
- Sensory neuronal sensitisation occurs through HMGB-1–RAGE and TRPV1 in high-glucose conditions
Summary: In high-glucose conditions, nociceptive neurons are sensitised through the actions of HMGB1 acting though RAGE and PKC. This sensitisation is blocked by a VEGF-A splice variant.
- N-linked glycosylation plays a crucial role in the secretion of HMGB1
Highlighted Article: HMGB1 N-glycosylation is a prerequisite for its nucleocytoplasmic transport and extracellular secretion.