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HMGB1

  • RESEARCH ARTICLE
    Sensory neuronal sensitisation occurs through HMGB-1–RAGE and TRPV1 in high-glucose conditions
    Samuel M. Bestall, Richard P. Hulse, Zoe Blackley, Matthew Swift, Nikita Ved, Kenneth Paton, Nicholas Beazley-Long, David O. Bates, Lucy F. Donaldson
    Journal of Cell Science 2018 131: jcs215939 doi: 10.1242/jcs.215939 Published 26 July 2018

    Summary: In high-glucose conditions, nociceptive neurons are sensitised through the actions of HMGB1 acting though RAGE and PKC. This sensitisation is blocked by a VEGF-A splice variant.

  • RESEARCH ARTICLE
    N-linked glycosylation plays a crucial role in the secretion of HMGB1
    Young Hun Kim, Man Sup Kwak, Jun Bae Park, Shin-Ae Lee, Ji Eun Choi, Hyun-Soo Cho, Jeon-Soo Shin
    Journal of Cell Science 2016 129: 29-38; doi: 10.1242/jcs.176412

    Highlighted Article: HMGB1 N-glycosylation is a prerequisite for its nucleocytoplasmic transport and extracellular secretion.

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