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Lipid nanocluster

  • RESEARCH ARTICLE
    A subset of flavaglines inhibits KRAS nanoclustering and activation
    Hajime Yurugi, Yinyin Zhuang, Farid A. Siddiqui, Hong Liang, Sebastian Rosigkeit, Yongpeng Zeng, Hussein Abou-Hamdan, Ernesto Bockamp, Yong Zhou, Daniel Abankwa, Wenting Zhao, Laurent Désaubry, Krishnaraj Rajalingam
    Journal of Cell Science 2020 133: jcs244111 doi: 10.1242/jcs.244111 Published 24 June 2020

    Summary: Rocaglamide, a flavagline and chemical ligand of PHB1, inhibits RAS GTP loading and KRAS nanoclustering at the plasma membrane. PHB1 might control KRAS activation by regulating the segregation of specific KRAS-binding phospholipid.

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