Lysosomal Degradation
- L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes
Summary: L-leucyl-L-leucine methyl ester (LLOMe) permeabilizes lysosomal membranes and destabilizes lysosomal enzymes. LLOMe-induced apoptosis is independent of cysteine cathepsin proteolytic activities in the cytosol.