Macrophages
- BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages
Summary: BCAT1 controls mitochondrial metabolism independently of its transamination role in activated human macrophages.
- The cationic amino acid exporter Slc7a7 is induced and vital in zebrafish tissue macrophages with sustained efferocytic activity
Highlighted Article: The cationic amino acid exporter Slc7a7 is rapidly induced in zebrafish tissue macrophages upon efferocytosis, allowing them to cope with the catabolism of numerous dead cells without compromising their own viability.
- Topical insulin application accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization
Summary: Overexpression of insulin-degrading enzyme leads to low insulin levels in diabetic wounds, resulting in dysfunction of neutrophils and macrophages. Supplying insulin promotes wound healing by inducing anti-inflammatory macrophage polarization.
- F-actin flashes on phagosomes mechanically deform contents for efficient digestion in macrophages
Summary: We find that internalized particles are mechanically deformed in macrophages, suggesting that the process of phagocytosis also employs a ‘chewing’ step to help destroy unwanted targets in macrophages.
- P2X7 receptor activation increases expression of caveolin-1 and formation of macrophage lipid rafts, thereby boosting CD39 activity
Summary: P2X7 receptor activation triggers the initiation of lipid raft-dependent regulatory pathways that upregulate CD39 activity, contributing to limit macrophage responses and inflammation.
- Discovery of aspirin-triggered eicosanoid-like mediators in a Drosophila metainflammation blood tumor model
Summary: Aspirin administration shrinks blood tumors and resolves inflammation in fruit flies. These effects correlate with high levels of linoleic acid-derived bioactive lipids.
- Tunneling nanotubes, a novel mode of tumor cell–macrophage communication in tumor cell invasion
Summary: A novel mechanism of intercellular communication through tunneling nanotubes (TNTs) on macrophage-mediated tumor cell invasion reveals TNTs as a potential therapeutic target.
- Common signalling pathways in macrophage and osteoclast multinucleation
Summary: This Review highlights the common signalling pathways in macrophage and osteoclast multinucleation. This basic cell phenomenon which underlies various complex diseases is poorly understood.
- RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis
Summary: RhoC accumulates at phagocytic cups and modulates an mDia1-dependent remodeling of cortical F-actin that is required for FcγR-mediated phagocytosis in macrophages.