Macrophages
- F-actin flashes on phagosomes mechanically deform contents for efficient digestion in macrophages
Summary: We find that internalized particles are mechanically deformed in macrophages, suggesting that the process of phagocytosis also employs a ‘chewing’ step to help destroy unwanted targets in macrophages.
- P2X7 receptor activation increases expression of caveolin-1 and formation of macrophage lipid rafts, thereby boosting CD39 activity
Summary: P2X7 receptor activation triggers the initiation of lipid raft-dependent regulatory pathways that upregulate CD39 activity, contributing to limit macrophage responses and inflammation.
- Discovery of aspirin-triggered eicosanoid-like mediators in a Drosophila metainflammation blood tumor model
Summary: Aspirin administration shrinks blood tumors and resolves inflammation in fruit flies. These effects correlate with high levels of linoleic acid-derived bioactive lipids.
- Tunneling nanotubes, a novel mode of tumor cell–macrophage communication in tumor cell invasion
Summary: A novel mechanism of intercellular communication through tunneling nanotubes (TNTs) on macrophage-mediated tumor cell invasion reveals TNTs as a potential therapeutic target.
- Common signalling pathways in macrophage and osteoclast multinucleation
Summary: This Review highlights the common signalling pathways in macrophage and osteoclast multinucleation. This basic cell phenomenon which underlies various complex diseases is poorly understood.
- RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis
Summary: RhoC accumulates at phagocytic cups and modulates an mDia1-dependent remodeling of cortical F-actin that is required for FcγR-mediated phagocytosis in macrophages.
- Rac1 switching at the right time and location is essential for Fcγ receptor-mediated phagosome formation
Highlighted Article: A novel mechanistic model for phagosome formation that is spatiotemporally controlled by Rac1 switching within a phagocytic cup.
- Drosophila WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization
Summary: Drosophila wash was originally described as an essential gene. We show that wash mutant flies are viable and fertile, and that WASH has conserved functions in integrin receptor recycling and lysosome neutralization.
- The formins FHOD1 and INF2 regulate inter- and intra-structural contractility of podosomes
Highlighted Article: This study identifies the formins FHOD1 and INF2 as new components of podosomes in primary human macrophages, which regulate inter- and intra-structural contractility at discrete podosome substructures.