Mechanical stress
- Role of epithelial Na+ channels in endothelial function
Summary: ENaCs endogenous to human endothelial cells are mechano-sensitive. Persistent activation of ENaCs will inevitably lead to endothelium dysfunction and even vascular diseases.
- Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane
Highlighted Article: Decreased membrane binding of PACSIN2 upon its PKC-mediated phosphorylation at serine 313 is shown to trigger the removal of caveolae from the plasma membrane.