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Metastasis

  • REVIEW
    The pleiotropic functions of autophagy in metastasis
    Timothy Marsh, Bhairavi Tolani, Jayanta Debnath
    Journal of Cell Science 2021 134: jcs247056 doi: 10.1242/jcs.247056 Published 22 January 2021

    Summary: A discussion of the diverse cell biological roles of autophagy that promote and suppress metastatic progression in cancer.

  • RESEARCH ARTICLE
    BMP4 promotes the metastasis of gastric cancer by inducing epithelial–mesenchymal transition via ID1
    Ganlu Deng, Yihong Chen, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Yaojie Fu, Changjing Cai, Hong Shen, Shan Zeng
    Journal of Cell Science 2020 133: jcs237222 doi: 10.1242/jcs.237222 Published 11 June 2020

    Summary: BMP4 is a novel prognostic factor for gastric cancer that modulates epithelial–mesenchymal transition to promote invasion and metastasis by increasing ID1 expression.

  • RESEARCH ARTICLE
    EML4–ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7
    Laura O'Regan, Giancarlo Barone, Rozita Adib, Chang Gok Woo, Hui Jeong Jeong, Emily L. Richardson, Mark W. Richards, Patricia A. J. Muller, Spencer J. Collis, Dean A. Fennell, Jene Choi, Richard Bayliss, Andrew M. Fry
    Journal of Cell Science 2020 133: jcs241505 doi: 10.1242/jcs.241505 Published 11 May 2020

    Summary: EML4–ALK fusions are major drivers of lung cancer. Particular fusion variants act through a novel actionable pathway involving NEK7 and NEK9, promoting cell migration and potentially influencing metastatic progression.

  • RESEARCH ARTICLE
    VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1
    Oisun Jung, DeannaLee M. Beauvais, Kristin M. Adams, Alan C. Rapraeger
    Journal of Cell Science 2019 132: jcs232645 doi: 10.1242/jcs.232645 Published 28 October 2019

    Summary: VEGFR2 docked to shed Sdc1 activates CXCR4- and VLA-4-dependent tumor cell migration. Blocking VEGFR2 docking prevents this migration while stimulating the migration of tumor-targeting T cells and NK cells.

  • RESEARCH ARTICLE
    Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes
    Elizabeth L. Zoeller, Brian Pedro, Jessica Konen, Bhakti Dwivedi, Manali Rupji, Niveda Sundararaman, Lei Wang, John R. Horton, Chaojie Zhong, Benjamin G. Barwick, Xiaodong Cheng, Elisabeth D. Martinez, Matthew P. Torres, Jeanne Kowalski, Adam I. Marcus, Paula M. Vertino
    Journal of Cell Science 2019 132: jcs231514 doi: 10.1242/jcs.231514 Published 9 October 2019

    Summary: Image-guided capture and sequencing of invasive cancer cells reveals novel leader- and follower-specific gene mutations, highlighting an important relationship between genomic and phenotypic heterogeneity during collective invasion.

  • RESEARCH ARTICLE
    Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential
    Tyler A. Allen, Dana Asad, Emmanuel Amu, M. Taylor Hensley, Jhon Cores, Adam Vandergriff, Junnan Tang, Phuong-Uyen Dinh, Deliang Shen, Li Qiao, Teng Su, Shiqi Hu, Hongxia Liang, Heather Shive, Erin Harrell, Connor Campbell, Xinxia Peng, Jeffrey A. Yoder, Ke Cheng
    Journal of Cell Science 2019 132: jcs231563 doi: 10.1242/jcs.231563 Published 9 September 2019

    Highlighted Article: Circulating tumor cell clusters spread throughout the body by using a unique method to exit blood vessels, which grants the tumor cells an increased ability to form secondary tumors.

  • RESEARCH ARTICLE
    Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1
    Yang Tian, Chunying Wang, Shuohua Chen, Jie Liu, Yan Fu, Yongzhang Luo
    Journal of Cell Science 2019 132: jcs228213 doi: 10.1242/jcs.228213 Published 31 July 2019

    Summary: Clusterin is identified to interact with extracellular Hsp90α and modulate its pro-metastatic function through increasing the binding affinity of eHsp90α and LRP1.

  • TOOLS AND RESOURCES
    The use of decellularised animal tissue to study disseminating cancer cells
    James F. E. Grey, Alastair Campbell-Ritchie, Nicola M. Everitt, Alexander J. Fezovich, Sally P. Wheatley
    Journal of Cell Science 2019 132: jcs219907 doi: 10.1242/jcs.219907 Published 10 December 2018

    Summary: Decellularised matrices derived from discarded animal-house material provide a physiologically relevant 3D-platform for studying cancer cell behaviour that is easy to use, inexpensive and embraces the 3Rs.

  • REVIEW
    Re-inforcing the cell death army in the fight against breast cancer
    Clara R. L. Oudenaarden, Robert A. H. van de Ven, Patrick W. B. Derksen
    Journal of Cell Science 2018 131: jcs212563 doi: 10.1242/jcs.212563 Published 23 August 2018

    Summary: Induction of BIM and BMF function in metastatic breast cancer can aid current treatment strategies.

  • RESEARCH ARTICLE
    LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
    Olivia Susanto, Yvette W. H. Koh, Nick Morrice, Sergey Tumanov, Peter A. Thomason, Matthew Nielson, Luke Tweedy, Andrew J. Muinonen-Martin, Jurre J. Kamphorst, Gillian M. Mackay, Robert H. Insall
    Journal of Cell Science 2017 130: 3455-3466; doi: 10.1242/jcs.207514

    Highlighted Article: Melanoma cells can create and follow their own gradients of attractant, via a new mechanism by which tumour cells may undergo metastasis.

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