Metastasis
- Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1
Summary: Clusterin is identified to interact with extracellular Hsp90α and modulate its pro-metastatic function through increasing the binding affinity of eHsp90α and LRP1.
- The use of decellularised animal tissue to study disseminating cancer cells
Summary: Decellularised matrices derived from discarded animal-house material provide a physiologically relevant 3D-platform for studying cancer cell behaviour that is easy to use, inexpensive and embraces the 3Rs.
- Re-inforcing the cell death army in the fight against breast cancer
Summary: Induction of BIM and BMF function in metastatic breast cancer can aid current treatment strategies.
- LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
Highlighted Article: Melanoma cells can create and follow their own gradients of attractant, via a new mechanism by which tumour cells may undergo metastasis.
- The CCR2 3′UTR functions as a competing endogenous RNA to inhibit breast cancer metastasis
Summary: The CCR2 3′UTR acts as a metastasis suppressor by acting as a competing endogenous RNA for STARD13 and thus inhibiting activation of the RhoA–ROCK1–MLC–F-actin pathway in breast cancer cells.
- Cancer cell behaviors mediated by dysregulated pH dynamics at a glance
Summary: Cancer cells have dysregulated pH dynamics and the increased intracellular pH enables a variety of cancer cell behaviors.
- The role and regulation of Rab40b–Tks5 complex during invadopodia formation and cancer cell invasion
Highlighted Article: Rab40b plays a key role in mediating invadopodia function during breast cancer cell invasion by binding to Tks5 and functioning as a tether mediating MMP2 and MMP9 targeting to the extending invadopodia.
- The CD44s splice isoform is a central mediator for invadopodia activity
Summary: CD44s, a splice isoform of the cell surface molecule CD44, plays an essential role in invadopodia activity and, consequently, metastasis during cancer progression.
- Fast and precise targeting of single tumor cells in vivo by multimodal correlative microscopy
Highlighted Article: We provide here a novel correlative workflow combining intravital microscopy, microCT and 3D electron microscopy to reveal metastatic events in mouse brain and skin tissue at high resolution.