Microtubule nucleation
- A SEPT1-based scaffold is required for Golgi integrity and function
Highlighted Article: SEPT1 associates with the Golgi complex through GM130, and is required for maintaining Golgi architecture and function by connecting cis-Golgi membranes to the microtubule-nucleating machinery.
- PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formation
Summary: PLK4 binds to microtubules and self-assembles into condensates that recruit tubulin and trigger de novo microtubule-organising centre formation in vitro.