MiR-206
- miR-206 enforces a slow muscle phenotype
Summary: miR-206 regulates the slow contractile properties of skeletal and cardiac muscle. miR-206 deletion shifts slow muscles to a faster profile and results in cardiac dysfunction specifically in male mice.
- MyoD transcription factor induces myogenesis by inhibiting Twist-1 through miR-206
Highlighted Article: We identify a mechanism of myogenesis in which MyoD and miR-206 downregulate the expression of Twist-1. This pathway might also play an important role in muscle disease.