Mouse
- MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation
Summary: cAMP efflux by MRP4 (ABCC4) has a critical role in controlling PKA activity and its effectors, as well as Ca2+ levels, thus affecting the fertilizing ability of mouse spermatozoa.
- The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss
Summary: The Clouston syndrome-causing connexin 30 mutant (Cx30-A88V) provides long-term protection against age-related hair cell death and hearing loss in mice.
- ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis
Summary: During valvulogenesis, opposing signals generated by different combinations of ErbB dimers regulate cell proliferation. HB-EGF-activated ErbB4 variant JM-A, which can release its intracellular domain, is required to suppress this proliferation.
- Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure
Summary: Actomyosin assembly and myosin ATPase activity are not essential for mouse spinal neurulation. However, the ROCK–LIMK–cofilin pathway, which controls actin turnover and actomyosin disassembly, is necessary.