Muscle
- Cell Tracking Profiler – a user-driven analysis framework for evaluating 4D live-cell imaging data
Summary: Analysis of cell shape and movement from 3D time-lapses is currently very challenging. Here, we develop Cell Tracking Profiler and use it to examine RhoA and myosin II control of muscle stem cell behaviour during zebrafish regeneration.
- An autophagy-dependent tubular lysosomal network synchronizes degradative activity required for muscle remodeling
Summary: Autophagy-dependent formation of an extensive Syntaxin17-marked tubular network synchronizes degradative activity across a broad region of remodeling muscle during Drosophila development.
- β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment
Highlighted Article: β1 integrin cytoplasmic splicing allows muscle cells to switch from a signaling to an anchoring and signaling-deficient phenotype through interaction with intracellular isoforms of adapter protein talin.
- A tissue communication network coordinating innate immune response during muscle stress
Summary: Activation of Drosophila innate immune responses is coordinated at local and systemic levels through tissue crosstalk following disruptions to muscle homeostasis.
- Integrin signaling downregulates filopodia during muscle–tendon attachment
Summary: Integrins signal through Git and Pak to downregulate filopodia when muscles reach their target attachment site in Drosophila.
- APC/CFzr regulates cardiac and myoblast cell numbers, and plays a crucial role during myoblast fusion
Highlighted Article: The anaphase-promoting complex has a novel and unexpected role during myoblast fusion.
- ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels
Highlighted Article: Here, we show that mice without ATAD3 in muscle develop a myopathy associated with early abnormal mitochondrial cristae structure, followed by defects in lipid transport and mitochondrial DNA maintenance.
- Aplip1, the Drosophila homolog of JIP1, regulates myonuclear positioning and muscle stability
Summary: Aplip1 (the Drosophila JIP1) regulates both myonuclear position and muscle stability during early muscle development through different Dynein and Kinesin-regulated mechanisms.
- Nestin contributes to skeletal muscle homeostasis and regeneration
Summary: Muscles from nestin-knockout mice have decreased mass, are prone to spontaneous degeneration/regeneration and have longer recovery time after injury. This phenotype is linked to disturbed proliferation of satellite cells.
- HIRA deficiency in muscle fibers causes hypertrophy and susceptibility to oxidative stress
Summary: Eliminating the histone chaperone HIRA from mouse skeletal muscle produced a hypertrophic response, compromised sarcolemmal integrity and left muscle fibers that were susceptible to stress-induced degeneration.