Muscle
- β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment
Highlighted Article: β1 integrin cytoplasmic splicing allows muscle cells to switch from a signaling to an anchoring and signaling-deficient phenotype through interaction with intracellular isoforms of adapter protein talin.
- A tissue communication network coordinating innate immune response during muscle stress
Summary: Activation of Drosophila innate immune responses is coordinated at local and systemic levels through tissue crosstalk following disruptions to muscle homeostasis.
- Integrin signaling downregulates filopodia during muscle–tendon attachment
Summary: Integrins signal through Git and Pak to downregulate filopodia when muscles reach their target attachment site in Drosophila.
- APC/CFzr regulates cardiac and myoblast cell numbers, and plays a crucial role during myoblast fusion
Highlighted Article: The anaphase-promoting complex has a novel and unexpected role during myoblast fusion.
- ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels
Highlighted Article: Here, we show that mice without ATAD3 in muscle develop a myopathy associated with early abnormal mitochondrial cristae structure, followed by defects in lipid transport and mitochondrial DNA maintenance.
- Aplip1, the Drosophila homolog of JIP1, regulates myonuclear positioning and muscle stability
Summary: Aplip1 (the Drosophila JIP1) regulates both myonuclear position and muscle stability during early muscle development through different Dynein and Kinesin-regulated mechanisms.
- Nestin contributes to skeletal muscle homeostasis and regeneration
Summary: Muscles from nestin-knockout mice have decreased mass, are prone to spontaneous degeneration/regeneration and have longer recovery time after injury. This phenotype is linked to disturbed proliferation of satellite cells.
- HIRA deficiency in muscle fibers causes hypertrophy and susceptibility to oxidative stress
Summary: Eliminating the histone chaperone HIRA from mouse skeletal muscle produced a hypertrophic response, compromised sarcolemmal integrity and left muscle fibers that were susceptible to stress-induced degeneration.
- Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction
Summary: The Drosophila proteoglycan Kon-tiki/Perdido enhances αPS2βPS integrin adhesion and localizes its ligand, Thrombospondin. This would lead to increased integrin adhesion to the ECM, and consolidation of the muscle–tendon junction.
- The NF-κB-modulated microRNAs miR-195 and miR-497 inhibit myoblast proliferation by targeting Igf1r, Insr and cyclin genes
Summary: miR-195 and miR-497 are negatively regulated by the myogenic factor NF-κB, and they could inhibit myoblast proliferation through targeting the Igf1r, Insr and cyclin genes.