Myofibroblasts
- TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts
Highlighted Article: TGF-β signaling suppresses the expression of the Wnt transcription factor TCF7L2 and compromises TCF7L2-dependent functions in tissue-resident PDGFRα+ fibroblasts.
- TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression
Summary: TGFβ, a master regulator of fibrosis, epigenetically represses anti-fibrotic gene expression via HDACs to promote fibroblast activation.