Neuron
- TrkB deubiquitylation by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation
Summary: USP8 interacts with and deubiquitylates TrkB neurotrophin receptors, regulating levels of both total and activated receptors and BDNF-dependent differentiation of hippocampal neurons.
- Monoallelic, antisense and total RNA transcription in an in vitro neural differentiation system based on F1 hybrid mice
Summary: A quantification of the dynamics of monoallelic, antisense and poly(A)− expression, distinction between poly(A)+ and poly(A)− antisense transcripts, and bimorphic transcription during neural differentiation.
- Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK
Summary: Fz7 functions as a Wnt7b receptor to modulate dendrite development and complexity by coactivating the CaMKII and JNK signalling cascades.
- Axonal endoplasmic reticulum is very narrow
Summary: Using new methods of serial-section electron microscopy, the axonal ER is found to consist of unusually narrow tubules compared with ER tubules in other cells.
- Effects of mutating α-tubulin lysine 40 on sensory dendrite development
Highlighted Article: Neurons are enriched in post-translationally modified microtubules. Targeted mutagenesis of endogenous α-tubulin in flies reveals that dendrite branch refinement is altered by acetylation-blocking mutations.
- The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons
Summary: The cellular prion protein (PrPC) controls neuronal Ca2+ entry through ionotropic glutamate receptors and attenuates the process of Ca2+-induced Ca2+ release (CICR), which in turn limits mitochondrial Ca2+ uptake.
- 3D electron tomography of brain tissue unveils distinct Golgi structures that sequester cytoplasmic contents in neurons
Summary: The power of new 3D imaging technologies, and optimal preservation of tissue samples, has helped to identify previously uncharacterized Golgi structures that sequester cytoplasmic material in neurons.
- Sortilin regulates sorting and secretion of Sonic hedgehog
Highlighted Article: We report a new role for sortilin (Sort1) as a negative regulator of Sonic hedgehog trafficking to axons and secretion from cells.
- The effects of ER morphology on synaptic structure and function in Drosophila melanogaster
Highlighted Article: The ER within Drosophila motor nerve terminals forms a network of tubules. Loss of the fusion GTPase atlastin fragments synaptic ER. Alteration of ER structure decreases evoked neurotransmitter release.