Nuclear transport
- ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling
Summary: Phosphorylation by ERK1/2 stimulates transcriptional activity of hypoxia-inducible factor-2α by inhibiting its CRM1- and NES-dependent nuclear export.
- Prolines in the α-helix confer the structural flexibility and functional integrity of importin-β
Summary: Multiple prolines in the helical repeat of karyopherins play essential roles in the structural flexibility of these molecules and their passage through the nuclear pore complex, as well as in proper mitotic progression.
- Perforating the nuclear boundary – how nuclear pore complexes assemble
Summary: Nuclear pore complexes are the gatekeepers of the nuclear envelope. We summarize how these huge structures assemble from about a thousand individual proteins and integrate into the nuclear envelope.
- Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding
Summary: NTF2 reduces the diameter of the NPC, nuclear import of large cargos and nuclear size in a Ran-binding-dependent manner, in both Xenopus and mammalian cells.