Oligodendrocyte
- PTPα is required for laminin-2-induced Fyn–Akt signaling to drive oligodendrocyte differentiation
Summary: The receptor PTPα is an essential component of integrin and dystroglycan receptor complexes that transduce extrinsic laminin-2 signals into specific intracellular events to promote OL differentiation.
- Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes
Summary: The RNA helicase DDX5 is a novel component of heterogeneous complexes containing Mbp mRNA, regulating post-transcriptional expression of MBP levels and isoform ratios in oligodendrocytes.
- MOBP levels are regulated by Fyn kinase and affect the morphological differentiation of oligodendrocytes
Summary: In oligodendrocytes, Fyn kinase regulates the synthesis of MOBP, and MOBP is required for establishing the complex cellular morphology of oligodendrocytes.