Osteoclast
- Primary myeloid cell proteomics and transcriptomics: importance of β-tubulin isotypes for osteoclast function
Summary: Analysis of proteomic and transcriptomic data of primary myeloid cells reveals that the β-tubulin isotype Tubb6 participates in osteoclast podosome patterning, sealing zone structure and resorption activity.
- Catabolic activity of osteoblast lineage cells contributes to osteoclastic bone resorption in vitro
Summary: Osteoblast lineage cells directly stimulate osteoclastic bone resorption and promote the aggressive trench-resorption mode by exerting a matrix metalloproteinase-dependent catabolic activity.
- Time-lapse reveals that osteoclasts can move across the bone surface while resorbing
Summary: Bone erosion requires that osteoclasts both resorb and migrate. According to common belief, these activities are mutually exclusive and alternate. Paradoxically, we show here simultaneous resorption and migration.
- Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity
Summary: Tensin 3 regulates podosome patterning in osteoclasts and bone resorption. Here, we show that tensin 3 is a partner of the Rac exchange factor Dock5 that stimulates its activity.
- KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK–NFATc1 signaling axis
Summary: The inwardly rectifying K+ channel KCNK1 negatively regulates osteoclast differentiation.