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Osteoclast

  • REVIEW
    The osteoclast cytoskeleton – current understanding and therapeutic perspectives for osteoporosis
    Anne Blangy, Guillaume Bompard, David Guerit, Pauline Marie, Justine Maurin, Anne Morel, Virginie Vives
    Journal of Cell Science 2020 133: jcs244798 doi: 10.1242/jcs.244798 Published 1 July 2020

    Summary: Osteoclasts are an amazing model to study interactions between cytoskeleton components; their role in osteoclast bone resorption activity can also open opportunities for the treatments against osteoporosis, as reviewed here.

  • RESEARCH ARTICLE
    Primary myeloid cell proteomics and transcriptomics: importance of β-tubulin isotypes for osteoclast function
    David Guérit, Pauline Marie, Anne Morel, Justine Maurin, Christel Verollet, Brigitte Raynaud-Messina, Serge Urbach, Anne Blangy
    Journal of Cell Science 2020 133: jcs239772 doi: 10.1242/jcs.239772 Published 27 May 2020

    Summary: Analysis of proteomic and transcriptomic data of primary myeloid cells reveals that the β-tubulin isotype Tubb6 participates in osteoclast podosome patterning, sealing zone structure and resorption activity.

  • RESEARCH ARTICLE
    Catabolic activity of osteoblast lineage cells contributes to osteoclastic bone resorption in vitro
    Dinisha Cyril Pirapaharan, Jacob Bastholm Olesen, Thomas Levin Andersen, Sandra Bjerre Christensen, Per Kjærsgaard-Andersen, Jean-Marie Delaisse, Kent Søe
    Journal of Cell Science 2019 132: jcs229351 doi: 10.1242/jcs.229351 Published 15 May 2019

    Summary: Osteoblast lineage cells directly stimulate osteoclastic bone resorption and promote the aggressive trench-resorption mode by exerting a matrix metalloproteinase-dependent catabolic activity.

  • RESEARCH ARTICLE
    Time-lapse reveals that osteoclasts can move across the bone surface while resorbing
    Kent Søe, Jean-Marie Delaissé
    Journal of Cell Science 2017 130: 2026-2035; doi: 10.1242/jcs.202036

    Summary: Bone erosion requires that osteoclasts both resorb and migrate. According to common belief, these activities are mutually exclusive and alternate. Paradoxically, we show here simultaneous resorption and migration.

  • RESEARCH ARTICLE
    Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity
    Heiani Touaitahuata, Anne Morel, Serge Urbach, Julio Mateos-Langerak, Sylvain de Rossi, Anne Blangy
    Journal of Cell Science 2016 129: 3449-3461; doi: 10.1242/jcs.184622

    Summary: Tensin 3 regulates podosome patterning in osteoclasts and bone resorption. Here, we show that tensin 3 is a partner of the Rac exchange factor Dock5 that stimulates its activity.

  • RESEARCH ARTICLE
    KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK–NFATc1 signaling axis
    Jeong-Tae Yeon, Kwang-Jin Kim, Sang Woo Chun, Hae In Lee, Ji Yeon Lim, Young-Jin Son, Seong Hwan Kim, Sik-Won Choi
    Journal of Cell Science 2015 128: 3411-3419; doi: 10.1242/jcs.170738

    Summary: The inwardly rectifying K+ channel KCNK1 negatively regulates osteoclast differentiation.

  • RESEARCH ARTICLE
    Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures
    Tristan W. Fowler, Archana Kamalakar, Nisreen S. Akel, Richard C. Kurten, Larry J. Suva, Dana Gaddy
    Journal of Cell Science 2015 128: 683-694; doi: 10.1242/jcs.157834

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