osteogenesis
- BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation
Summary: GDF5 mutants were used to investigate the role of BMPR1A and BMPR1B in chondrogenesis and osteogenesis. We found that BMPR1A is necessary for chondrogenesis and osteogenesis, and BMPR1B prevents hypertrophy.
- Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts
Summary: Both N- and O-glycan processing modulate MSC differentiation early during osteogenesis to influence mineral formation. Inhibition of N-glycan processing increases mineralization.