p62
- p62/SQSTM1 – steering the cell through health and disease
Summary: Here, we review the functions of the multifunctional SQSTM1 (p62) protein based on its post-translational modifications, as well as how its deregulation is involved in multiple human diseases.
- The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy
Highlighted Article: NEDD4 is an autophagic HECT E3 ubiquitin ligase that ubiquitylates the autophagy receptor SQSTM1, facilitating inclusion body autophagy.
- Regulation of glucose metabolism by p62/SQSTM1 through HIF1α
Highlighted Article: p62 is a crucial positive regulator of HIF1α, which is a facilitating factor in p62-enhanced tumorigenesis.