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Paxillin

  • RESEARCH ARTICLE
    Adhesion, motility and matrix-degrading gene expression changes in CSF-1-induced mouse macrophage differentiation
    Michael W. Murrey, James H. Steer, Eloise L. Greenland, Julie M. Proudfoot, David A. Joyce, Fiona J. Pixley
    Journal of Cell Science 2020 133: jcs232405 doi: 10.1242/jcs.232405 Published 2 March 2020

    Summary: Widespread and profound changes occur in the expression of adhesion, motility and matrix-degrading genes as macrophages differentiate under the influence of CSF-1; the roles of paxillin and leupaxin adhesion proteins are compared.

  • RESEARCH ARTICLE
    β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment
    Martinho Soto-Ribeiro, Birgit Kastberger, Michael Bachmann, Latifeh Azizi, Kenza Fouad, Marie-Claude Jacquier, David Boettiger, Daniel Bouvard, Martin Bastmeyer, Vesa P. Hytönen, Bernhard Wehrle-Haller
    Journal of Cell Science 2019 132: jcs224493 doi: 10.1242/jcs.224493 Published 25 April 2019

    Highlighted Article: β1 integrin cytoplasmic splicing allows muscle cells to switch from a signaling to an anchoring and signaling-deficient phenotype through interaction with intracellular isoforms of adapter protein talin.

  • RESEARCH ARTICLE
    Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin
    Juan Gao, Ming Huang, Jingjing Lai, Kaijun Mao, Peisen Sun, Zhongyuan Cao, Youpei Hu, Yingying Zhang, Marie L. Schulte, Chaozhi Jin, Jian Wang, Gilbert C. White, Zhen Xu, Yan-Qing Ma
    Journal of Cell Science 2017 130: 3764-3775; doi: 10.1242/jcs.205641

    Summary: Kindlin supports integrin αIIbβ3 activation by forming a complex with paxillin and talin and thus enhancing talin binding to integrin.

  • RESEARCH ARTICLE
    Distinct focal adhesion protein modules control different aspects of mechanotransduction
    Ben Stutchbury, Paul Atherton, Ricky Tsang, De-Yao Wang, Christoph Ballestrem
    Journal of Cell Science 2017 130: 1612-1624; doi: 10.1242/jcs.195362

    Summary: Quantitative fluorescence microscopy shows that focal adhesions are composed of functional protein modules, which control distinct aspects of mechanotransduction.

  • RESEARCH ARTICLE
    A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells
    Silvia M. Goicoechea, Ashtyn Zinn, Sahezeel S. Awadia, Kyle Snyder, Rafael Garcia-Mata
    Journal of Cell Science 2017 130: 1064-1077; doi: 10.1242/jcs.195552

    Highlighted Article: We describe a novel signaling pathway involving SGEF, RhoG and paxillin phosphorylation, which functions in the regulation of invadopodia disassembly in breast cancer cells.

  • SHORT REPORT
    Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains
    Aneesh R. Sathe, G. V. Shivashankar, Michael P. Sheetz
    Journal of Cell Science 2016 129: 1981-1988; doi: 10.1242/jcs.172643

    Summary: We find that nuclear translocation of paxillin is tuned by focal adhesion maturation. This could provide a method for mechanosensing signals to be used by cells to control transcription.

  • RESEARCH ARTICLE
    Paxillin-dependent regulation of IGF2 and H19 gene cluster expression
    Pavel Marášek, Rastislav Dzijak, Irina Studenyak, Jindřiška Fišerová, Lívia Uličná, Petr Novák, Pavel Hozák
    Journal of Cell Science 2015 128: 3106-3116; doi: 10.1242/jcs.170985

    Summary: A new regulatory pathway whereby paxillin mediates the expression of two growth-related genes, IGF2 and H19, is presented, uncovering a role for paxillin in cell proliferation.

  • RESEARCH ARTICLE
    TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly
    Pradeep D. Uchil, Tobias Pawliczek, Tracy D. Reynolds, Siyuan Ding, Angelika Hinz, James B. Munro, Fang Huang, Robert W. Floyd, Haitao Yang, William L. Hamilton, Joerg Bewersdorf, Yong Xiong, David A. Calderwood, Walther Mothes
    Journal of Cell Science 2014 127: 3928-3942; doi: 10.1242/jcs.143537
  • RESEARCH ARTICLE
    Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression
    Alexandra E. German, Tadanori Mammoto, Elisabeth Jiang, Donald E. Ingber, Akiko Mammoto
    Journal of Cell Science 2014 127: 1672-1683; doi: 10.1242/jcs.132316
  • RESEARCH ARTICLE
    ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines
    Simone Radtke, Mina Milanovic, Carine Rossé, Manu De Rycker, Sylvie Lachmann, Andrew Hibbert, Stéphanie Kermorgant, Peter J. Parker
    Journal of Cell Science 2013 126: 2381-2391; doi: 10.1242/jcs.115832

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