Paxillin
- β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment
Highlighted Article: β1 integrin cytoplasmic splicing allows muscle cells to switch from a signaling to an anchoring and signaling-deficient phenotype through interaction with intracellular isoforms of adapter protein talin.
- Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin
Summary: Kindlin supports integrin αIIbβ3 activation by forming a complex with paxillin and talin and thus enhancing talin binding to integrin.
- Distinct focal adhesion protein modules control different aspects of mechanotransduction
Summary: Quantitative fluorescence microscopy shows that focal adhesions are composed of functional protein modules, which control distinct aspects of mechanotransduction.
- A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells
Highlighted Article: We describe a novel signaling pathway involving SGEF, RhoG and paxillin phosphorylation, which functions in the regulation of invadopodia disassembly in breast cancer cells.
- Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains
Summary: We find that nuclear translocation of paxillin is tuned by focal adhesion maturation. This could provide a method for mechanosensing signals to be used by cells to control transcription.
- Paxillin-dependent regulation of IGF2 and H19 gene cluster expression
Summary: A new regulatory pathway whereby paxillin mediates the expression of two growth-related genes, IGF2 and H19, is presented, uncovering a role for paxillin in cell proliferation.