Phosphatidylserine
- Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria
Summary: Overexpression of the mitochondrial targeting sequence of ATP5G1 perturbs glucose metabolism, and translocates K-Ras to mitochondria and phosphatidylserine to endomembranes, through regulation of PI4P content at the Golgi.
- Structure and function analysis of the C. elegans aminophospholipid translocase TAT-1
Summary: The structure–function relationship of the C. elegans P4-ATPase TAT-1 and identification of two highly conserved motifs that are especially important for the TAT-1 phosphatidylserine flippase activity.
- Ypk1 and Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodeling after membrane stresses
Summary: Yeast resists plasma membrane stress by maintaining the cortical localization of Rho GTPase through lipid remodeling mediated by Ypk kinase and flippase.
- Activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis
Summary: NO from microglia causes reversible caspase activation and phosphatidylserine exposure by PC12 cells, resulting in their cell death by phagocytosis.