PKC
- Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt
Summary: The highly related but functionally distinct kinases, Akt and SGK1, are uniquely targeted by mTORC2; SGK1, but not Akt, requires mTORC2 phosphorylation at a perinuclear compartment for its activation.
- CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways
Highlighted Article: The cancer-related tetraspanin protein CD151 uses novel pathways to mediate the regulation of FGFR2 expression.
- Keratin impact on PKCδ- and ASMase-mediated regulation of hepatocyte lipid raft size – implication for FasR-associated apoptosis
Summary: Hepatocytes express keratin 8 (K8) and 18 (K18) as their sole intermediate filaments. A loss of K8/K18 impacts on PKCδ- and ASMase-mediated modulation of lipid raft size and FasR-mediated apoptosis.
- Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of the MAPKKK Mkh1
Summary: Spatial regulation of MAPKKK proteins remains poorly characterized in fission yeast. Skb5, an SH3 adaptor, was shown to attenuate Pmk1 MAPK signaling by regulating the subcellular distribution of the Mkh1 MAPKKK.