Primary cilium
- The conserved ancestral signaling pathway from cilium to nucleus
Summary: Here, we propose a hypothesis to answer the question of why so many signaling molecules that work in the nucleus are also found in the primary cilium.
- Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia
Summary: Gli2 knockout in fibroblasts lengthens primary cilia through enhanced autophagy-mediated Ofd1 degradation. This ciliary lengthening delays cell cycle re-entry – an unexpected mechanism for cell cycle regulation.
- Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis
Summary: We identify a functional interaction between Pcnt and Syne-2, which is required for centrosomal and nuclear attachment, and photoreceptor outer segment formation.
- CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity
Summary: Knockout of the CEP164 ciliopathy gene ablates ciliogenesis but causes no increase in sensitivity to DNA damage induced by ionising or ultraviolet irradiation.
- A role for Rab23 in the trafficking of Kif17 to the primary cilium
Highlighted Article: The small GTPase Rab23 mediates the transport of the kinesin-2 motor Kif17 to the primary cilium by interacting with it and its adaptor importin β2.
- Ciliary adenylyl cyclases control the Hedgehog pathway
Summary: Ciliary adenylyl cyclases AC5 and AC6 respond to stimulatory and inhibitory GPCRs to control PKA and, hence, transduce the Hedgehog signal.