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Protein–protein interaction

  • RESEARCH ARTICLE
    Cdc24 interacts with septins to create a positive feedback loop during bud site assembly in yeast
    Julian Chollet, Alexander Dünkler, Anne Bäuerle, Laura Vivero-Pol, Medhanie A. Mulaw, Thomas Gronemeyer, Nils Johnsson
    Journal of Cell Science 2020 133: jcs240283 doi: 10.1242/jcs.240283 Published 11 June 2020

    Summary: The Cdc42 guanine-nucleotide-exchange factor Cdc24 interacts with septins during bud site assembly. This interaction assists in recruiting septins and stabilizing Cdc24 at the incipient bud site.

  • RESEARCH ARTICLE
    Two conserved glycine residues in mammalian and Dictyostelium Rictor are required for mTORC2 activity and integrity
    Barbara Pergolizzi, Cristina Panuzzo, M. Shahzad Ali, Marco Lo Iacono, Chiara Levra Levron, Luca Ponzone, Marta Prelli, Daniela Cilloni, Enzo Calautti, Salvatore Bozzaro, Enrico Bracco
    Journal of Cell Science 2019 132: jcs236505 doi: 10.1242/jcs.236505 Published 14 November 2019

    Summary: Two glycine residues are essential for the mTORC2 activity and integrity in organisms that are distantly related, suggesting they have a conserved role in mTORC2 assembly and functioning.

  • TOOLS AND RESOURCES
    High-content tripartite split-GFP cell-based assays to screen for modulators of small GTPase activation
    Faten Koraïchi, Rémi Gence, Catherine Bouchenot, Sarah Grosjean, Isabelle Lajoie-Mazenc, Gilles Favre, Stéphanie Cabantous
    Journal of Cell Science 2018 131: jcs210419 doi: 10.1242/jcs.210419 Published 8 January 2018

    Summary: The development of a fluorescent reporter of GTPase activation based on tripartite split-GFP that enables the evaluation of GEF activity and the effect of modulators of GTPase activation in a high-content analysis.

  • RESEARCH ARTICLE
    Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC
    Hui You, Yamei Ge, Jian Zhang, Yizhi Cao, Jing Xing, Dongming Su, Yujie Huang, Min Li, Shen Qu, Fei Sun, Xiubin Liang
    Journal of Cell Science 2017 130: 1027-1036; doi: 10.1242/jcs.198242

    Summary: Derlin-1 binds to ENaC and promotes its ubiquitylation and degradation via ER-related degradation. The E3 ligase HUWE1 is required and adds K11-linked ubiquitin chains to ENaC prompting its degradation.

  • SHORT REPORT
    Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain
    Ahmed Handhle, Chloe E. Ormonde, N. Lowri Thomas, Catherine Bralesford, Alan J. Williams, F. Anthony Lai, Spyros Zissimopoulos
    Journal of Cell Science 2016 129: 3983-3988; doi: 10.1242/jcs.191643

    Summary: Direct physical and functional calsequestrin 2 association with the ryanodine receptor luminal domain is the minimal requirement to form the sarcoplasmic reticulum Ca2+ sensor, which governs cardiac Ca2+ homeostasis and reliable heartbeat.

  • RESEARCH ARTICLE
    FoxO1 inhibits transcription and membrane trafficking of epithelial Na+ channel
    Yachen Shen, Weifeng Xu, Hui You, Dongming Su, Jing Xing, Min Li, Lei Li, Xiubin Liang
    Journal of Cell Science 2015 128: 3621-3630; doi: 10.1242/jcs.171876

    Summary: FoxO1 is a key negative regulatory factor in the insulin-dependent control of ENaC expression, and FoxO1 phosphorylation promotes ENaC membrane trafficking by binding to 14-3-3ε in epithelium.

  • RESEARCH ARTICLE
    Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins
    Yohei Katoh, Shohei Nozaki, David Hartanto, Rie Miyano, Kazuhisa Nakayama
    Journal of Cell Science 2015 128: 2351-2362; doi: 10.1242/jcs.168740

    Highlighted Article: The architectures of the BBSome and exocyst are revealed by a visible immunoprecipitation assay, which can detect interactions between fluorescent fusion proteins without performing western blotting.

  • RESEARCH ARTICLE
    GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade
    Zongyong Zhang, Wenhua Zhang, Siluo Huang, Qian Sun, Yunyun Wang, Yongjian Hu, Ninghua Sun, Yilei Zhang, Zhihua Jiang, Nagahiro Minato, Jean-Philippe Pin, Li Su, Jianfeng Liu
    Journal of Cell Science 2015 128: 2302-2313; doi: 10.1242/jcs.167056

    Summary: GABAB receptor activation induces Rap1 activation to promote its own surface expression by stimulating receptor recycling, thereby providing a potential explanation for the long-lasting action of GABA.

  • RESEARCH ARTICLE
    Stepwise and cooperative assembly of a cytokinetic core complex in Saccharomyces cerevisiae
    Chen Tian, Yehui Wu, Nils Johnsson
    Journal of Cell Science 2014 127: 3614-3624; doi: 10.1242/jcs.153429

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