Protein complex
- Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)
Highlighted Article: A cytoplasmic domain within the ubiquitin ligase Hrd1 recruits cofactors necessary for ligase oligomerisation and activity, which are important for ER-associated degradation (ERAD).
- Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes
Summary: Development is more sensitive to gain of vinculin activity than its loss, and vinculin can promote cytoplasmic adhesion complexes independently of the usual integrin cue.