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Protein complex

  • RESEARCH ARTICLE
    Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)
    Jasmin Schulz, Dönem Avci, Markus A. Queisser, Aljona Gutschmidt, Lena-Sophie Dreher, Emma J. Fenech, Norbert Volkmar, Yuki Hayashi, Thorsten Hoppe, John C. Christianson
    Journal of Cell Science 2017 130: 3322-3335; doi: 10.1242/jcs.206847

    Highlighted Article: A cytoplasmic domain within the ubiquitin ligase Hrd1 recruits cofactors necessary for ligase oligomerisation and activity, which are important for ER-associated degradation (ERAD).

  • RESEARCH ARTICLE
    Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes
    Aidan P. Maartens, Jutta Wellmann, Emma Wictome, Benjamin Klapholz, Hannah Green, Nicholas H. Brown
    Journal of Cell Science 2016 129: 4354-4365; doi: 10.1242/jcs.189878

    Summary: Development is more sensitive to gain of vinculin activity than its loss, and vinculin can promote cytoplasmic adhesion complexes independently of the usual integrin cue.

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