Protein folding
- Ribosome-associated quality control of membrane proteins at the endoplasmic reticulum
Summary: In this review, we describe how errors in membrane protein biogenesis can trigger co-translational degradation that employs machinery of the ribosome-associated quality control pathway.
- The pivotal role of ERp44 in patrolling protein secretion
Summary: A review of how ERp44 is key in sculpting the composition of the secretome and of the organelles of the early secretory pathway.
- The mammalian cytosolic thioredoxin reductase pathway acts via a membrane protein to reduce ER-localised proteins
Summary: Correct disulfuide formation in the secretory pathway requires reducing equivalents from the cytosol mediated through a membrane protein localised to the endoplasmic reticulum.
- Squaring the EMC – how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis
Summary: The EMC is an important factor facilitating membrane protein biogenesis. Here we discuss the broad cellular and organismal responsibilities overseen by client proteins requiring the EMC for maturation.
- A clearer picture of the ER translocon complex
Summary: Different cryo-EM approaches, ranging from analysis of isolated molecules to in situ imaging, have yielded many new insights into the main gate of the secretory pathway.