Protein sorting
- The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ER
Summary: The GET machinery can, in principle, process mitochondrial proteins but, under normal conditions, active mitochondrial targeting pathways dominate the kinetic competition against GET recognition.
- The retromer, sorting nexins and the plant endomembrane protein trafficking
Summary: Studying sorting nexins (SNXs) has revealed unique aspects of plant endomembrane trafficking. In this Review, we present the current knowledge, and unclarified functions and perspectives on SNX-mediated plant protein recycling.
- The role of palmitoylation and transmembrane domain in sorting of transmembrane adaptor proteins
Summary: Palmitoylation and proximal sequences can function as secondary sorting signals for membrane proteins with suboptimal transmembrane domains.
- A microtubule-independent role of p150glued in secretory cargo concentration at endoplasmic reticulum exit sites
Summary: p150glued stabilizes COPII pre-budding complexes on ER exit sites in a microtubule-independent manner, and it coordinates protein sorting, carrier formation and long-range transport events.