PtdIns(4,5)P2
- Phosphatidylinositol 4,5-bisphosphate regulates cilium transition zone maturation in Drosophila melanogaster
Summary: The membrane phospholipid PIP2, and the kinase that produces PIP2, called Skittles, are needed for normal ciliary transition zone morphology and function in the Drosophila male germline.
- Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient RNA polymerase II-dependent transcription
Summary: A novel nuclear structure – nuclear lipid islets – might serve as a structural platform for the formation of Pol II transcription factories, thus participating in the formation of transcription-competent architecture.
- Emerging roles of PtdIns(4,5)P2 – beyond the plasma membrane
Summary: In this Commentary, we review current evidence supporting intracellular PtdIns(4,5)P2 signaling, with a focus on PtdIns(4,5)P2 regulation of endolysosomal trafficking and protein recycling, as well as autophagic membrane trafficking.