SGK
- Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt
Summary: The highly related but functionally distinct kinases, Akt and SGK1, are uniquely targeted by mTORC2; SGK1, but not Akt, requires mTORC2 phosphorylation at a perinuclear compartment for its activation.
- Akt and SGK protein kinases are required for efficient feeding by macropinocytosis
Summary: Dictyostelium feed by macropinocytosis in a PIP3-dependent manner. Macropinosomes are smaller and fluid uptake is nearly abolished in cells lacking either PI3Ks or the downstream kinases PkbA and PkbR1.