Skin
- RAS-mediated suppression of PAR3 and its effects on SCC initiation and tissue architecture occur independently of hyperplasia
Highlighted Article: Temporal analysis of human neoplasia identifies PAR3 as a critical regulator of E-cadherin-mediated cell adhesion and oriented cell division during initial human SCC development.
- Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion
Summary: Integrin-αv plays a crucial role in regulating skin tissue generation and tumor invasion through a focal-adhesion-independent FAK–p38–p90RSK–c-Myc signaling axis.