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Small GTPase

  • SHORT REPORT
    Rap1 and membrane lipids cooperatively recruit talin to trigger integrin activation
    Thomas Bromberger, Liang Zhu, Sarah Klapproth, Jun Qin, Markus Moser
    Journal of Cell Science 2019 132: jcs235531 doi: 10.1242/jcs.235531 Published 1 November 2019

    Summary: Talin requires cooperative Rap1 binding to its F0 and F1 domains and lipid binding to the F2 domain for its recruitment to adhesion sites to trigger integrin activation.

  • RESEARCH ARTICLE
    The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane
    Ekaterina Revenkova, Qing Liu, G. Luca Gusella, Carlo Iomini
    Journal of Cell Science 2018 131: jcs212324 doi: 10.1242/jcs.212324 Published 4 May 2018

    Summary: The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.

  • RESEARCH ARTICLE
    Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos
    Miho Oka, Keisuke Hashimoto, Yoshifumi Yamaguchi, Shin-ichiro Saitoh, Yuki Sugiura, Yuji Motoi, Kurara Honda, Yorifumi Kikko, Shinya Ohata, Makoto Suematsu, Masayuki Miura, Kensuke Miyake, Toshiaki Katada, Kenji Kontani
    Journal of Cell Science 2017 130: 3568-3577; doi: 10.1242/jcs.200519

    Summary: The small GTPase Arl8b, known to be involved in lysosomal function, contributes to mouse embryonic growth by mediating lysosomal degradation of maternal proteins in the visceral yolk sac endoderm.

  • RESEARCH ARTICLE
    The F-actin-binding RapGEF GflB is required for efficient macropinocytosis in Dictyostelium
    Hironori Inaba, Koji Yoda, Hiroyuki Adachi
    Journal of Cell Science 2017 130: 3158-3172; doi: 10.1242/jcs.194126

    Summary: Dictyostelium GflB, known as a Rap1 GEF, interacts with F-actin via its N-terminal villin headpiece (VHP)-like domain and regulates macropinocytic and phagocytic cup formation and retraction.

  • RESEARCH ARTICLE
    Microscopy analysis of reconstituted COPII coat polymerization and Sec16 dynamics
    Hirohiko Iwasaki, Tomohiro Yorimitsu, Ken Sato
    Journal of Cell Science 2017 130: 2893-2902; doi: 10.1242/jcs.203844

    Highlighted Article: COPII components mediate the formation of transport carriers from the ER. Fluorescence microscopy analysis of artificial planar membrane is used to define the dynamics of COPII coat polymerization.

  • RESEARCH ARTICLE
    Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2
    Kohichi Matsunaga, Masato Taoka, Toshiaki Isobe, Tetsuro Izumi
    Journal of Cell Science 2017 130: 541-550; doi: 10.1242/jcs.195479

    Summary: Although regulated exocytosis comprises several sequential steps, the mechanisms coordinating each step are poorly understood. These findings suggest that Noc2 regulates the transition between Rab2a- and Rab27a-mediated exocytosis.

  • RESEARCH ARTICLE
    PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a
    Mami Yamaoka, Tomomi Ando, Takeshi Terabayashi, Mitsuhiro Okamoto, Masahiro Takei, Tomoki Nishioka, Kozo Kaibuchi, Kohichi Matsunaga, Ray Ishizaki, Tetsuro Izumi, Ichiro Niki, Toshimasa Ishizaki, Toshihide Kimura
    Journal of Cell Science 2016 129: 637-649; doi: 10.1242/jcs.180141

    Summary: The insulin secretagogue glucose activates PI3K and induces endocytosis through promoting signaling crosstalk between Arf6 and Rab27a pathways.

  • RESEARCH ARTICLE
    Mon1–Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells
    Sayaka Yasuda, So Morishita, Akane Fujita, Tomohisa Nanao, Naoyuki Wada, Satoshi Waguri, Giampietro Schiavo, Mitsunori Fukuda, Takeshi Nakamura
    Journal of Cell Science 2016 129: 329-340; doi: 10.1242/jcs.178095

    Highlighted Article: A combination of a Rab7 sensor and confocal FRET imaging techniques revealed that the Mon1–Ccz1 complex activates Rab7 only on late endosome and dissociates from lysosome in mammalian cells.

  • RESEARCH ARTICLE
    P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
    George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins
    Journal of Cell Science 2014 127: 2589-2600; doi: 10.1242/jcs.153049
  • RESEARCH ARTICLE
    Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes
    Morié Ishida, Norihiko Ohbayashi, Yuto Maruta, Yuka Ebata, Mitsunori Fukuda
    Journal of Cell Science 2012 125: 5177-5187; doi: 10.1242/jcs.109314

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